The research team used four quadrant prospective evaluation method of endoscopic biopsy for 322 Barrett esophageal patients, in the histologic after biopsy and flow cytometric analysis. Each of these patients at least a follow-up evaluation, 41 cases were detected, 34 cases of cancer is detected in five years.

Researchers in July of the American Journal of Gastroenterology (up) reported: Gastroenterology, think "namely results not aneuploidy no 4 times of chromosomes diagnosis unknown or low-grade atypical patients for five years, but have severe dysplasia 0% aneuploidy or 4 times of severe dysplasia patients increased chromosome 28%. This means that the risk factors for no patients can be delayed again after 5 years".
Dr Reid said "has four times more chromosomes and aneuploid chromosomes and highly atypical patients with severe dysplasia 5 years respectively, 43% and 59%, 56% flow cytometric detection with abnormal more worth often follow-up."

Four quadrant endoscopic biopsy method has advantages compared with traditional methods, usually endoscopic biopsy samples taken experts will more than 4 pieces, this study from 322 patients get huge amount of biopsy specimens, half for histologic detection, half for flow cytometric detection. Four quadrant endoscopic biopsy method through aneuploidy, four times more chromosomes and highly atypical index in 5 years to detect 34 cancer patients, and two quadrant method to detect 82% only aneuploid 76 percent of patients, chromosome aneuploidy and/or 4 times the chromosome increased patients and 59 percent of patients with atypical height.

Normal esophageal squamous mucosa coating layer, such as local squamous mucosa was columnar epithelium, is called Barrett esophagus. Early in 1805 Schmidt in his essays first described in the esophagus ectopic gastric mucosa island, but did not cause the medical attention. Until the 1950 Barrett Barett) in Britain (the surgical magazine reported lower esophageal mucosal coating columnar epithelium lesions, and in 1957 and made a detailed description on the medical attention, caused the esophagus. Then the author says the columnar mucosa, such as Barrett esophageal squamous esophageal. Clinic for Barrett's esophagus) is not uncommon.barrett, upper rate (1.4% ~ clans report), average 16.3%respectively.

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